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Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):83-94. doi: 10.1517/17425250903463878.

Pharmacology and clinical use of voriconazole.

Author information

1
University of Texas, Health Science Center at San Antonio, Division of Infectious Diseases, Department of Medicine, San Antonio, TX 78229-3900, USA. thompsong2@uthscsa.edu

Abstract

IMPORTANCE OF THE FIELD:

Voriconazole is an extended-spectrum triazole developed specifically to target Aspergillus spp. and is now indicated as primary therapy in this circumstance. However, it has a broad spectrum of activity against both yeasts and molds and is also a viable treatment option in the treatment of other mycoses.

AREAS COVERED IN THIS REVIEW:

This review discusses the mechanism of action, the pharmacodynamics and pharmacokinetics and the most common mechanisms of resistance to this agent. An overview of therapeutic drug monitoring, drug-drug interactions and pivotal trials are also reviewed.

WHAT THE READER WILL GAIN:

The reader will gain further knowledge of the unique aspects of voriconazole compared to other currently available antifungal agents.

TAKE HOME MESSAGE:

Voriconazole offers distinct advantages over several other antifungals. The side effect profile of voriconazole is unique compared to other triazole agents. Concern for drug-drug interactions due to a frequently shared common metabolic pathway has prompted heightened interest in the use of therapeutic drug monitoring for concerns of toxicity, drug-drug interactions and in attempts to ensure efficacy. These aspects as well as a review of important clinical information pertaining to voriconazole are discussed here.

PMID:
19947892
DOI:
10.1517/17425250903463878
[Indexed for MEDLINE]

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