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Annu Rev Immunol. 2010;28:131-55. doi: 10.1146/annurev-immunol-030409-101250.

Properdin: emerging roles of a pattern-recognition molecule.

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1
MRC Centre for Transplantation, King's College London, United Kingdom. claudia.kemper@kcl.ac.uk

Abstract

Complement is an innate immune system that is a first line of defense against pathogens and facilitates elimination of apoptotic and injured cells. During complement activation, the complement convertases are assembled on target surfaces and initiate their proteolytic activities, a process that marks targets for phagocytosis and/or lysis. The complement alternative activation pathway has been implicated in a number of autoimmune conditions including arthritis and age-related macular degeneration. Properdin, a plasma component that is also released by activated neutrophils, is critical in the stabilization of alternative pathway convertases. Recently, it has been shown that properdin is also a pattern-recognition molecule that binds to certain microbial surfaces, apoptotic cells, and necrotic cells. Once bound to a surface, properdin can direct convertase formation and target uptake. New studies are now focusing on a role for properdin in inflammatory and autoimmune diseases. This review examines the new properdin findings and their implications.

[Indexed for MEDLINE]

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