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Nat Rev Microbiol. 2010 Jan;8(1):8-14. doi: 10.1038/nrmicro2266.

The molecular basis of the host response to lipopolysaccharide.

Author information

1
Clare E. Bryant is at the Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 OES, UK. ceb27@cam.ac.uk

Abstract

Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.

PMID:
19946286
DOI:
10.1038/nrmicro2266
[Indexed for MEDLINE]
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