Format

Send to

Choose Destination
See comment in PubMed Commons below
Rheumatology (Oxford). 2010 Feb;49(2):211-7. doi: 10.1093/rheumatology/kep374. Epub 2009 Nov 27.

The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome.

Author information

1
3rd Department of Medicine, Division of Clinical Immunology, Medical and Health Science Centre, University of Debrecen, Moricz Zs. str. 22, 4032 Debrecen, Hungary. szodoray@gmail.com

Abstract

OBJECTIVE:

The aim of the present study was to investigate the immunomodulating role of fat-soluble vitamins in 25 patients with primary SS (pSS) and 15 healthy individuals.

METHODS:

Plasma levels of vitamins A, D and E were determined by HPLC. Peripheral NK, NK T cells, T-cell subsets, B cells, IL-10 producing Tr1 cells, CD4(+)CD25(+) Treg cells and Th17 were determined by flow cytometry. Various Th1- and Th2-soluble cytokines were assessed by ELISA, whereas intracytoplasmic cytokines (IFN-gamma, IL-4, -10 and -17) were measured by flow cytometry. Correlation was assessed between vitamin levels and immunological and clinical parameters.

RESULTS:

Vitamin A levels did not differ between patients and controls, yet in patients with extraglandular manifestations (EGMs) a significant decrease in vitamin A levels was apparent compared with pSS patients without EGMs (P = 0.005). Vitamin E levels were increased in patients compared with controls (P = 0.004), whereas vitamin D levels were similar in pSS and control subjects. In patients, vitamin A showed a positive correlation with both NK cell (P = 0.038) and Th17 cell (P = 0.025), and a negative correlation with Schirmer's test values (P = 0.035). Positive correlation was found between vitamin E and NK cells (P = 0.043), Th1 cells (P = 0.049) and the Th1/Th2 ratio (P = 0.043). In the control group, we found correlation between vitamin E and serum IL-10 levels (P = 0.003).

CONCLUSIONS:

Our data suggest that fat-soluble vitamins may be important in immunoregulatory processes in patients with pSS.

PMID:
19946023
DOI:
10.1093/rheumatology/kep374
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center