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Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 2009 Nov 27.

mTOR and cancer: many loops in one pathway.

Author information

1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, United States.

Abstract

The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.

PMID:
19945836
PMCID:
PMC2854285
DOI:
10.1016/j.ceb.2009.10.007
[Indexed for MEDLINE]
Free PMC Article

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