Format

Send to

Choose Destination
Neurosurg Clin N Am. 2010 Jan;21(1):31-42. doi: 10.1016/j.nec.2009.08.005.

Glioblastoma-derived mechanisms of systemic immunosuppression.

Author information

1
Department of Neurosurgery, University of Colorado Health Sciences Center, 12631 E. 17th Avenue, Aurora, CO 80045, USA. allen.waziri@uchsc.edu

Abstract

Abnormalities of cellular immunity are commonly seen in patients with glioblastoma (GBM), and the subsequent relative immunosuppression likely contributes to poor tumor-specific responses in affected individuals. Endogenous immune regulation is likely to limit the efficacy of a wide array of immunotherapeutic strategies, therefore mandating consideration in the continued development of novel treatments for GBM. Various tumor-associated factors have been implicated as potential generators of the immunosuppressive effect. This article outlines relevant experimentation exploring the nature of immune defects in patients with GBM, including a critical discussion of tumor-secreted factors, cell-surface proteins, and more recently described populations of immunoregulatory leukocytes that have potential roles in the subversion of cellular immunity.

PMID:
19944964
DOI:
10.1016/j.nec.2009.08.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center