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Neurobiol Dis. 2010 Mar;37(3):534-41. doi: 10.1016/j.nbd.2009.11.016. Epub 2009 Nov 26.

Inflammation and central nervous system Lyme disease.

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  • 1Department of Psychiatry, Columbia University, New York, NY 10032, USA. baf1@columbia.edu

Abstract

Lyme disease, caused by the bacterium Borrelia burgdorferi, can cause multi-systemic signs and symptoms, including peripheral and central nervous system disease. This review examines the evidence for and mechanisms of inflammation in neurologic Lyme disease, with a specific focus on the central nervous system, drawing upon human studies and controlled research with experimentally infected rhesus monkeys. Directions for future human research are suggested that may help to clarify the role of inflammation as a mediator of the chronic persistent symptoms experienced by some patients despite antibiotic treatment for neurologic Lyme disease.

PMID:
19944760
DOI:
10.1016/j.nbd.2009.11.016
[PubMed - indexed for MEDLINE]
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