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Food Chem Toxicol. 2010 Feb;48(2):639-43. doi: 10.1016/j.fct.2009.11.045. Epub 2009 Nov 26.

Anti-inflammatory activity of seed essential oil from Zizyphus jujuba.

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Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.


This study was undertaken to evaluate the effect of essential oil from seeds of Zizyphus jujuba on TPA-induced skin inflammation in experimental mice. Exposure of TPA on the ear of the BALB/c mice caused a marked increase in both ear thickness and skin water content. The ear thickness was measured for TPA-induced ear was 0.54 mm, as compared to control (0.23 mm). Treatment with 1% and 10% of essential oil caused significant decrease in ear thicknesses which were measured to be 0.30 and 0.35 mm, as well as reduce the water content about 51% and 53% in the TPA-induced skin inflammation model, respectively. Furthermore, histological analysis clearly confirmed that Z. jujuba essential oil inhibited the inflammatory responses of skin inflammation in animal model. Therefore, our findings demonstrate that the essential oil of Z. jujuba seeds might accelerate the development of new drugs for various inflammatory diseases.

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