Format

Send to

Choose Destination
See comment in PubMed Commons below
Obstet Gynecol Clin North Am. 2009 Dec;36(4):809-29, x. doi: 10.1016/j.ogc.2009.10.001.

Sleep, hormones, and memory.

Author information

1
Department of Neuroendocrinology, University of Lübeck, Haus 23a, Lübeck, Germany. born@kfg.uni-luebeck.de

Abstract

Nocturnal sleep is characterized by a unique pattern of endocrine activity, which comprises reciprocal influences on the hypothalamo-pituitary-adrenal (HPA) and the somatotropic system. During early sleep, when slow wave sleep (SWS) prevails, HPA secretory activity is suppressed whereas growth hormone (GH) release reaches a maximum; this pattern is reversed during late sleep when rapid eye movement (REM) sleep predominates. SWS benefits the consolidation of hippocampus-dependent declarative memories, whereas REM sleep improves amygdala-dependent emotional memories and procedural skill memories involving striato-cortical circuitry. Manipulation of plasma cortisol and GH concentration during sleep revealed a primary role of HPA activity for memory consolidation. Pituitary-adrenal inhibition during SWS sleep represents a prerequisite for efficient consolidation of declarative memory; increased cortisol during late REM sleep seems to protect from an overshooting consolidation of emotional memories.

PMID:
19944302
DOI:
10.1016/j.ogc.2009.10.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center