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Bioorg Med Chem. 2010 Jan 1;18(1):151-7. doi: 10.1016/j.bmc.2009.11.007. Epub 2009 Nov 10.

Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.

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Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc, 194 Ichiba, Kagamino 708-0393, Japan.


The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors.

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