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Trends Microbiol. 2010 Jan;18(1):30-7. doi: 10.1016/j.tim.2009.11.001. Epub 2009 Nov 26.

Sense and sensibility: flagellum-mediated gene regulation.

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1
Department of Microbiology, University of Georgia, Athens, Georgia 30602, USA.

Abstract

The flagellum, a rotary engine required for motility in many bacteria, plays key roles in gene expression. It has been known for some time that flagellar substructures serve as checkpoints that coordinate flagellar gene expression with assembly. Less well understood, however, are other more global effects on gene expression. For instance, the flagellum acts as a 'wetness' sensor in Salmonella typhimurium, and as a mechanosensor in other bacteria. Additionally, it has been implicated in a variety of bacterial processes, including biofilm formation, pathogenesis and symbiosis. Although for many of these processes it might be simply that motility is required, in other cases it seems that the flagellum plays an underappreciated role in regulating gene expression.

PMID:
19942438
PMCID:
PMC2818477
DOI:
10.1016/j.tim.2009.11.001
[Indexed for MEDLINE]
Free PMC Article
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