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Leuk Res. 2010 Feb;34(2):258-60. doi: 10.1016/j.leukres.2009.11.001. Epub 2009 Nov 25.

Telomerase gene mutation screening in Chinese patients with aplastic anemia.

Author information

1
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1, Shuai Fuyuan, Dongcheng District, Beijing 100730, China. hanbing_li@sina.com.cn

Abstract

To study the incidence of telomerase gene mutations in Chinese patients with acquired bone marrow failure (BMF) and explore its relationship with telomere shortening. Blood samples from 66 patients with aplastic anemia (AA) in northern China were collected and TERC mutation analysis was performed. Two TERC mutations were identified. The incidence of telomerase gene mutations in Chinese people with acquired AA is similar to that of the western people.

PMID:
19942288
DOI:
10.1016/j.leukres.2009.11.001
[Indexed for MEDLINE]

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