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Mol Cell. 2009 Nov 25;36(4):541-6. doi: 10.1016/j.molcel.2009.10.019.

Progression through the RNA polymerase II CTD cycle.

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1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. steveb@hms.harvard.edu

Abstract

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.

PMID:
19941815
PMCID:
PMC3232742
DOI:
10.1016/j.molcel.2009.10.019
[Indexed for MEDLINE]
Free PMC Article
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