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Horm Res. 2009 Nov;72 Suppl 1:48-54. doi: 10.1159/000229764. Epub 2009 Nov 27.

Can growth hormone counteract the catabolic effects of steroids?

Author information

1
Division of Endocrinology, Nemours Children's Clinic, Jacksonville, FL 32207, USA. nmauras@nemours.org

Abstract

BACKGROUND:

Chronic administration of glucocorticosteroids (GCs) can have significant catabolic effects in vivo in a host of metabolic systems, including amino acid metabolism, skeletal muscle, bone and linear growth. GCs inhibit protein synthesis and increase protein breakdown at the skeletal muscle and whole-body level and impair growth hormone (GH) secretion and action. Conversely, GH and insulin-like growth factor I (IGF-I) are potent protein-anabolic and growth-promoting agents in vitro and in vivo. This review summarizes both the catabolic effects of GCs and the anabolic and metabolic effects of GH and IGF-I.

CONCLUSIONS:

Both GH and IGF-I may decrease the catabolic effects of chronic steroid use in humans, particularly by enhancing lean body mass accrual and, in children, by increasing linear growth.

PMID:
19940496
DOI:
10.1159/000229764
[Indexed for MEDLINE]

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