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Clin Vaccine Immunol. 2010 Jan;17(1):199-201. doi: 10.1128/CVI.00305-09. Epub 2009 Nov 25.

Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice.

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1
Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Abstract

Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.

PMID:
19940042
PMCID:
PMC2812077
DOI:
10.1128/CVI.00305-09
[Indexed for MEDLINE]
Free PMC Article
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