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J Med Assoc Thai. 2009 Nov;92(11):1560-6.

Basic principle of transcranial magnetic stimulation.

Author information

  • 1Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. aparad@kku.ac.th

Abstract

BACKGROUND:

Transcranial Magnetic Stimulation (TMS) is a new neurophysiological technique based on the principle of electromagnetic induction. When a pulse of current passes through a coil, it becomes a magnetic field and penetrates the scalp and skull, and reach the brain painlessly.

OBJECTIVE:

Review TMS stimulator, types of stimulation, mechanism of action, and its application.

MATERIAL AND METHOD:

There are three types of TMS stimulation: 1) Single pulse; used in studying of motor threshold and phosphene threshold. 2) Paired pulse; used in the study of intracortical inhibitory and facilitatory mechanisms. 3) Repetitive stimulation; changes corticospinal/corticocortical pathway.

RESULTS:

The mechanisms increases activity of synapse, changes the secretion of neurotransmitter and causes neuronal plasticity or long-term potentiation. Repetitive stimulation is used in fundamental basic science for brain mapping. It is a new therapeutic method for neuro-psychiatic disorders that does not respond to medications.

CONCLUSION:

TMS study is rapidly increasing and accepted as a noninvasive technique. The most favorable treating outcomes are depression and Parkinson disease. Other neuro-psychiatic therapeutic outcomes are ongoing.

PMID:
19938752
[PubMed - indexed for MEDLINE]
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