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World J Gastroenterol. 2009 Nov 28;15(44):5558-62.

Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis.

Author information

1
Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany.

Abstract

AIM:

To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP).

METHODS:

MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.

RESULTS:

The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021).

CONCLUSION:

In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP.

PMID:
19938194
PMCID:
PMC2785058
DOI:
10.3748/wjg.15.5558
[Indexed for MEDLINE]
Free PMC Article

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