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Mol Cell Biochem. 2010 Jan;334(1-2):99-103. doi: 10.1007/s11010-009-0327-7. Epub 2009 Nov 24.

A new Rac/PAK/GC/cGMP signaling pathway.

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1
Department of Physiology, Cornell University Weill Medical College, New York, NY 10065, USA.

Abstract

Guanosine 3',5'-cyclic monophosphate (cGMP) and small GTPase Rac are critical regulators of cell functions. Recently, Rac has been shown to use its downstream effector p21-activated kinase (PAK) to directly activate transmembrane guanylyl cyclases (GCs). This novel Rac/PAK/GC/cGMP signaling pathway bridges Rac and cGMP, and provides a general molecular mechanism for diverse receptors to regulate physiological functions such as cell migration through elevating the cellular cGMP level.

PMID:
19937092
PMCID:
PMC2832591
DOI:
10.1007/s11010-009-0327-7
[Indexed for MEDLINE]
Free PMC Article
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