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Nat Rev Immunol. 2009 Dec;9(12):858-70. doi: 10.1038/nri2670.

Tissue-mediated control of immunopathology in coeliac disease.

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1
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. bjabri@bsd.uchicago.edu

Abstract

Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation--induced either by infectious agents or by gluten--is crucial for activating T cells and eliciting their tissue-destructive effector functions.

PMID:
19935805
DOI:
10.1038/nri2670
[Indexed for MEDLINE]
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