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Neurosurgery. 2009 Dec;65(6 Suppl):226-36. doi: 10.1227/01.NEU.0000350868.95634.CA.

Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience.

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1
Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. zhangd@npg.wustl.edu

Abstract

OBJECTIVE:

To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection.

METHODS:

Resting-state blood oxygenation-dependent functional magnetic resonance imaging (fMRI) scans were acquired in 17 healthy young adults and 4 patients with brain tumors invading sensorimotor cortex. Conventional fMRI motor mapping (finger-tapping protocol) was also performed in the patients. Intraoperatively, motor hand area was mapped using cortical stimulation.

RESULTS:

Robust and consistent delineation of sensorimotor cortex was obtained using the resting-state blood oxygenation-dependent data. Resting-state functional mapping localized sensorimotor areas consistent with cortical stimulation mapping and in all patients performed as well as or better than task-based fMRI.

CONCLUSION:

Resting-state correlation mapping is a promising tool for reliable functional localization of eloquent cortex. This method compares well with "gold standard" cortical stimulation mapping and offers several advantages compared with conventional motor mapping fMRI.

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