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Diabetes Care. 2010 Feb;33(2):348-9. doi: 10.2337/dc09-0950. Epub 2009 Nov 23.

Role of quantitative bone scanning in the assessment of bone turnover in patients with Charcot foot.

Author information

1
Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. bemrob@yahoo.co.uk

Abstract

OBJECTIVE:

To assess the new quantitative bone scan parameters as markers of Charcot neuroosteoarthropathy (CNO) activity.

RESEARCH DESIGN AND METHODS:

Forty-two patients with acute (n = 21) and nonacute (n = 21) CNO underwent quantitative bone scanning. Patients with acute CNO were followed for 3-12 months and bone scans were repeated after treatment. New quantitative parameters were assessed and compared with markers of bone turnover and with skin temperature difference (STD).

RESULTS:

Significant correlations between quantitative bone scan parameters and bone turnover markers were observed (all P < 0.05). These parameters decreased after treatment of CNO, and its reduction to the baseline value correlated with differences of bone turnover markers and STD (all P < 0.05).

CONCLUSIONS:

Our study suggests that bone scanning can be used not only for diagnosis of CNO but also for monitoring disease activity by quantitative bone scan parameters.

PMID:
19933988
PMCID:
PMC2809280
DOI:
10.2337/dc09-0950
[Indexed for MEDLINE]
Free PMC Article

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