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AJR Am J Roentgenol. 2009 Dec;193(6):1500-3. doi: 10.2214/AJR.09.3365.

Imaging findings in a fatal case of pandemic swine-origin influenza A (H1N1).

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1
Department of Radiology and Imaging Sciences, National Institutes of Health, Clinical Center, Bethesda, MD, USA.

Abstract

OBJECTIVE:

Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) have been self-limited, fatal cases raise questions about virulence and radiology's role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection.

CONCLUSION:

Radiography showed peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.

Comment in

PMID:
19933640
PMCID:
PMC2788497
DOI:
10.2214/AJR.09.3365
[Indexed for MEDLINE]
Free PMC Article
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