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Bioorg Med Chem Lett. 2010 Jan 1;20(1):418-21. doi: 10.1016/j.bmcl.2009.07.119. Epub 2009 Jul 29.

Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Author information

1
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.

Abstract

Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.

PMID:
19932964
DOI:
10.1016/j.bmcl.2009.07.119
[Indexed for MEDLINE]

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