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FEBS Lett. 2010 Jan 21;584(2):318-24. doi: 10.1016/j.febslet.2009.11.056.

The T box mechanism: tRNA as a regulatory molecule.

Author information

1
Department of Microbiology, Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

Abstract

The T box mechanism is widely used in Gram-positive bacteria to regulate expression of aminoacyl-tRNA synthetase genes and genes involved in amino acid biosynthesis and uptake. Binding of a specific uncharged tRNA to a riboswitch element in the nascent transcript causes a structural change in the transcript that promotes expression of the downstream coding sequence. In most cases, this occurs by stabilization of an antiterminator element that competes with formation of a terminator helix. Specific tRNA recognition by the nascent transcript results in increased expression of genes important for tRNA aminoacylation in response to decreased pools of charged tRNA.

PMID:
19932103
PMCID:
PMC2794906
DOI:
10.1016/j.febslet.2009.11.056
[Indexed for MEDLINE]
Free PMC Article

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