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Transfus Apher Sci. 2010 Feb;42(1):63-70. doi: 10.1016/j.transci.2009.10.008. Epub 2009 Nov 20.

Novel and unexpected clearance mechanisms for cold platelets.

Author information

1
Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Abstract

Storage at room temperature is limited to 5 days because of the risk of bacterial growth and loss of platelet functionality. Platelet refrigeration remains impossible, because once chilled, platelets are rapidly removed from circulation. Chilling platelets (<4h) clusters glycoprotein (GP) Ibalpha receptors, and beta(2) integrins on hepatic macrophages recognize clustered beta GlcNAc residues leading to rapid clearance of acutely chilled platelets. Prolonged refrigeration increases the exposure of galactose residues such that, unexpectedly, hepatocytes remove platelets using their asialoglycoprotein receptors. Here we review current knowledge of the mechanisms of platelet removal, the existing knowledge of refrigerated platelet function, and methods to preserve platelet concentrates long-term for transfusion.

PMID:
19932055
PMCID:
PMC4303245
DOI:
10.1016/j.transci.2009.10.008
[Indexed for MEDLINE]
Free PMC Article

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