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Semin Cell Dev Biol. 2010 Feb;21(1):66-71. doi: 10.1016/j.semcdb.2009.11.013. Epub 2009 Nov 28.

Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions.

Author information

1
Department of Pathology and Laboratory Medicine, 6051 Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI 53705-2275, United States. afriedl@wisc.edu

Abstract

Reciprocal interactions between tumor and stromal cells govern carcinoma growth and progression. Signaling functions between these cell types in the tumor microenvironment are largely carried out by secreted growth factors and cytokines. This review discusses how proteoglycans, which are abundantly present in normal and neoplastic tissues, modulate paracrine growth factor signaling events. General principles of proteoglycan involvement in paracrine signaling include stromal induction, core protein processing by proteases and growth factor binding via proteoglycan glycosaminoglycan chains or core protein domains.

PMID:
19931629
PMCID:
PMC2824000
DOI:
10.1016/j.semcdb.2009.11.013
[Indexed for MEDLINE]
Free PMC Article

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