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J Biol. 2009;8(10):88. doi: 10.1186/jbiol195.

The nature of cell-cycle checkpoints: facts and fallacies.

Author information

1
Wadsworth Center, Albany, NY 12201-0509, USA. khodj@wadsworth.org

Abstract

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.

PMID:
19930621
PMCID:
PMC2790835
DOI:
10.1186/jbiol195
[Indexed for MEDLINE]
Free PMC Article

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