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Biochem Biophys Res Commun. 1991 Jan 31;174(2):1009-14.

A quantifiable phenotype of viral propagation.

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Max-Planck-Institute for Biophysical Chemistry, Department of Biochemical Kinetics, Göttingen, Federal Republic of Germany.


A system has been identified where a virus, replicating continuously on its host, displays a distinct and quantifiable phenotype, and thereby continuously reports on the state of the virus-host relationship. When bacteriophage T7 is plated out with its host, Escherichia coli, it establishes a constant-velocity infection wave, which is driven by an autocatalytic reaction-diffusion mechanism. The velocity--which is easily measured--continuously reflects the infection environment. The simplicity of the system extends to the investigator an unprecedented ability to monitor and control a viral infection process.

[Indexed for MEDLINE]

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