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Br J Haematol. 2010 Feb;148(3):476-9. doi: 10.1111/j.1365-2141.2009.07996.x. Epub 2009 Nov 23.

Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE) - lack of interference by iron deposition.

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1
Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S.), UnitĂ  Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy. vito.dimarco@tin.it

Abstract

The correlation between liver stiffness, measured by transient elastography, liver fibrosis, using the histological METAVIR score, and iron overload, measured by atomic absorption spectrometry was evaluated in 56 homozygous-beta-thalassaemics. Liver stiffness increased proportionally to liver fibrosis staging (r = 0.70; P > 0.001) independently of liver iron concentration (r = 0.01; P = 0.932). The area under the receiver-operating characteristic curve for prediction of cirrhosis was 0.997 (95% confidence interval [CI]: 0.925-1.000) with cut-off of 13 kPa with 100% sensitivity (95% CI: 69.0-100.0) and 95% specificity (95% CI: 84.2-99.3). Transient elastography is a reliable non-invasive tool for diagnosing advanced liver fibrosis in homozygous-beta-thalassaemics, regardless of the degree of iron overload.

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