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Clin Chem Lab Med. 2010;48(1):95-8. doi: 10.1515/CCLM.2010.004.

Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia.

Author information

1
The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. venkat.nimhans@yahoo.com

Abstract

BACKGROUND:

Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.

METHODS:

In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.

RESULTS:

Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001).

CONCLUSIONS:

The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.

PMID:
19929755
DOI:
10.1515/CCLM.2010.004
[Indexed for MEDLINE]

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