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Amyotroph Lateral Scler. 2009;10 Suppl 2:61-6. doi: 10.3109/17482960903273445.

BMAA neurotoxicity in Drosophila.

Author information

1
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Abstract

We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.

PMID:
19929734
DOI:
10.3109/17482960903273445
[Indexed for MEDLINE]

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