Format

Send to

Choose Destination
See comment in PubMed Commons below
Radiat Res. 2009 Dec;172(6):653-65. doi: 10.1667/RR1926.1.

Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.

Author information

1
Radiation Oncology Department, Duke University Medical Center, Durham, Durham, NC 27710, USA. dewhi001@mc.duke.edu

Abstract

This Failla Lecture focused on the inter-relationships between tumor angiogenesis, HIF-1 expression and radiotherapy responses. A common thread that bonds all of these factors together is microenvironmental stress caused by reactive oxygen and nitrogen species formed during tumor growth and angiogenesis or in response to cytotoxic treatment. In this review we focus on one aspect of the crossroad between oxidative stress and angiogenesis, namely cycling hypoxia. Understanding of the relative importance of this feature of the tumor microenvironment has recently expanded; it influences tumor biology in ways that are separate from chronic hypoxia. Cycling hypoxia can influence angiogenesis, treatment responses and metastatic behavior. It represents an important and relatively less well understood feature of tumor biology that requires additional research.

PMID:
19929412
PMCID:
PMC2790140
DOI:
10.1667/RR1926.1
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioOne Icon for PubMed Central
    Loading ...
    Support Center