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Adv Exp Med Biol. 2009;656:30-40.

APC in cell migration.

Author information

1
Institut Pasteur CNRS URA, Paris, France. sandrine.etienne-manneville@pasteur.fr

Abstract

Adenomatous Polyposis Coli (APC) is a tumor suppressor protein involved in the initiation and progression of colon cancer. The most widely accepted function ofAPC is to participate to the Wnt signaling pathway, by downregulating beta-catenin and thereby controlling gene transcription and cell proliferation. However, APC is clearly a multifunctional protein whose loss contributes to tumor formation in multiple ways. Regulation of APC localization during cell migration and the ability of APC to bind multiple polarity proteins and microtubule-associated molecules support the idea that APC plays a key role in directed cell migration and that this function may contribute to its tumour suppressor activity.

PMID:
19928350
DOI:
10.1007/978-1-4419-1145-2_3
[Indexed for MEDLINE]

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