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Stroke. 2010 Jan;41(1):173-6. doi: 10.1161/STROKEAHA.109.562264. Epub 2009 Nov 19.

Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study.

Author information

1
Department of Neurology, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.

Abstract

BACKGROUND AND PURPOSE:

To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state.

METHODS:

We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups.

RESULTS:

A total of 63 patients with MMD, 71 patients with non-MMD stroke, and 200 healthy control subjects were included. The prevalence of elevated thyroid autoantibodies was higher in the MMD group than in other groups (P<0.01 for MMD versus non-MMD; P<0.001 for MMD versus control subjects). After adjusting for covariates, the elevated thyroid autoantibodies (OR, 4.871; 95% CI, 1.588 to 15.277) and smoking habits (OR, 0.206 for current smoker; 95% CI, 0.054 to 0.786) were independently associated with MMD versus non-MMD stroke.

CONCLUSIONS:

Elevated thyroid autoantibodies were frequently observed in patients with MMD. The results of the present study suggest that immune aberrancies associated with or underlying thyroid autoimmunity are also playing a role in developing MMD.

PMID:
19926842
DOI:
10.1161/STROKEAHA.109.562264
[Indexed for MEDLINE]

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