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Cell Cycle. 2009 Dec 15;8(24):4067-71. Epub 2009 Dec 17.

DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response.

Author information

1
Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.

Abstract

DDB2 was identified as a protein involved in the Nucleotide Excision Repair (NER), a major DNA repair mechanism that repairs UV damage to prevent accumulation of mutations and tumorigenesis. However, recent studies indicated additional functions of DDB2 in the DNA damage response pathway. Herein, we discuss the proposed mechanisms by which DDB2 activates NER and programmed cell death upon DNA damage through its E3 ligase activity.

PMID:
19923893
PMCID:
PMC3107032
DOI:
10.4161/cc.8.24.10109
[Indexed for MEDLINE]
Free PMC Article

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