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J Biomed Mater Res B Appl Biomater. 2010 Jan;92(1):226-35. doi: 10.1002/jbm.b.31509.

In vitro colonization of an experimental silicone by Candida albicans.

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Department of Infection, Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Research, University College London, London, UK.


Denture soft-lining materials are exposed to the oral cavity for long periods and are in continuous contact with saliva, subject to inhibition of liquid molecules, and susceptible to colonization by microorganisms. The opportunist yeast Candida albicans is of particular concern in this context, being associated with denture plaque and denture-related stomatitis. In this study, penetration of C. albicans into an experimental silicone elastomer soft-lining material was investigated under batch and continuous culture conditions. A model "denture plaque" microcosm was also used. Increasing the filler concentration within the elastomer decreased penetration under both batch and continuous culture conditions. In continuous culture, C. albicans penetration was significantly greater in pure culture than in the presence of bacteria after 72-h incubation (p < 0.05).

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