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Cell Tissue Res. 2010 Jan;339(1):83-92. doi: 10.1007/s00441-009-0892-9. Epub 2009 Nov 17.

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms.

Author information

1
Department of Cell Biology, Radboud University Nijmegen Medical Centre, The Netherlands.

Abstract

Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to integrins, other adhesion systems mediate adhesion and cytoskeletal coupling to the extracellular matrix (ECM). These include multifunctional cell surface receptors (syndecans and CD44) and discoidin domain receptors, which together coordinate ligand binding with direct or indirect cytoskeletal coupling and intracellular signalling. We review the way that the different adhesion systems for ECM components impact cell migration in two- and three-dimensional migration models. We further discuss the hierarchy of these concurrent adhesion systems, their specific tasks in cell migration and their contribution to migration in three-dimensional multi-ligand tissue environments.

PMID:
19921267
PMCID:
PMC2784868
DOI:
10.1007/s00441-009-0892-9
[Indexed for MEDLINE]
Free PMC Article

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