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Transplantation. 2009 Sep 27;88(6):762-5. doi: 10.1097/TP.0b013e3181b4749f.

Fatal human herpesvirus-6 infection after renal transplantation.

Author information

1
Department of Renal Medicine, Auckland City Hospital, Grafton, Auckland, New Zealand. hpilmore@adhb.govt.nz

Abstract

INTRODUCTION:

Human herpesvirus (HHV)-6 infection is common after organ transplantation; however, most cases are associated with a mild clinical course. Donor-derived infection is rare, and there are no reports of HHV-6 infection in more than one recipient from a common donor.

METHODS:

We describe two patients who developed severe, and in one case fatal, HHV-6 variant A infection after renal transplantation.

RESULTS:

Both patients presented with severe colitis followed by the development of liver dysfunction and cytopenia. Multiple specimens from both recipients were positive for HHV-6 polymerase chain reaction variant A. Serum and white cells from the donor were positive for HHV-6 DNA, suggesting a donor-derived infection in these patients.

CONCLUSIONS:

We report two cases of donor-derived HHV-6 infection from the same deceased donor, resulting in a fatal outcome in one patient. Treatment with valganciclovir was successfully instigated in one patient with a full recovery from the infection.

PMID:
19920774
DOI:
10.1097/TP.0b013e3181b4749f
[Indexed for MEDLINE]

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