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Cancer Res. 2009 Dec 1;69(23):8835-8. doi: 10.1158/0008-5472.CAN-09-1676. Epub 2009 Nov 17.

Siah proteins: novel drug targets in the Ras and hypoxia pathways.

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Cancer Genomics and Genetics Laboratory, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria, Australia.


The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah proteins as tumor suppressors, recent studies in mouse models have shown that Siah inhibition impairs tumor growth and metastasis. Given their central role in oncogenic and angiogenic pathways, Siah proteins are attractive novel therapeutic targets in cancer.

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