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Fitoterapia. 2010 Jul;81(5):306-14. doi: 10.1016/j.fitote.2009.11.001. Epub 2009 Nov 14.

Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals.

Author information

1
Department of Pharmaceutical Sciences, HNB Garhwal University Srinagar, Garhwal, India. semaltyajay@gmail.com

Abstract

The poor and/or erratic oral bioavailability of polyphenolics can be improved using the PHYTOSOME delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids show affinity for polyphenolics, and form supramolecular adducts having a definite stoichiometry. This article reviews the preparation and characterization of PHYTOSOME complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application.

PMID:
19919847
DOI:
10.1016/j.fitote.2009.11.001
[Indexed for MEDLINE]

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