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Histopathology. 2009 Dec;55(6):705-8. doi: 10.1111/j.1365-2559.2009.03437.x.

Ketamine cystitis as a mimic of carcinoma in situ.

Author information

1
Department of Cellular Pathology, Southmead Hospital, Bristol, UK. jon.oxley@nbt.nhs.uk

Abstract

AIMS:

To describe the histopathological features of a series of patients with ketamine-related cystitis.

METHODS AND RESULTS:

Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20.

CONCLUSIONS:

Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.

[Indexed for MEDLINE]

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