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J Med Chem. 2009 Dec 24;52(24):7946-9. doi: 10.1021/jm9015334.

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.

Author information

1
Neuroscience Chemistry, Pfizer Global Research and Development, Groton, CT 06340, USA.

Abstract

By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.

PMID:
19919087
DOI:
10.1021/jm9015334
[Indexed for MEDLINE]

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