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Cases J. 2009 Aug 10;2:8551. doi: 10.4076/1757-1626-2-8551.

Granular cell tumor of the breast: a case report and review of literature.

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Institute of Pathology, Medical Faculty, University of "St Cyrill and Methodius" Street Vodnjanska bb, Skopje, 1000 Republic of Macedonia.


A 22-year-old female patient presented with a breast mass lesion with a clinical suspicion of a fibroadenoma. Histological evaluation revealed a rare benign neoplasm - granular cell tumor.Granular cell tumor is rare neoplasm that may arise in virtually any body site, and in 5% it occurs in the breast. The histogenesis of this tumor is still rather controversial and currently the most acceptable theory is a Schwann cell origin. The main histological feature is granular cytoplasm of the tumor cells.From a clinical point of view there is a similarity between granular cell tumor and mammary carcinoma on mammography and ultrasound. Pathohistologically, sometimes, differential diagnostic difficulties exist concerning apocrine carcinoma, histiocytic lesions and metastatic neoplasms.

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