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Nat Neurosci. 2010 Jan;13(1):22-4. doi: 10.1038/nn.2459. Epub 2009 Nov 15.

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1.

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1
Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Abstract

In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons. TSP1 interacted with neuroligin 1 (NL1) and application of the NL1 extracellular domain blocked TSP1-induced synaptogenesis. Furthermore, knocking down endogenous NL1 inhibited TSP1's effect. Our results indicate that TSP1 accelerates the speed of synaptogenesis through NL1 in hippocampal neurons.

PMID:
19915562
DOI:
10.1038/nn.2459
[Indexed for MEDLINE]

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