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Nat Chem Biol. 2009 Dec;5(12):885-7. doi: 10.1038/nchembio.252. Epub 2009 Nov 8.

Translating metabolic exchange with imaging mass spectrometry.

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  • 1University of California, San Diego, La Jolla, USA.

Abstract

Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor.

PMID:
19915536
PMCID:
PMC2778862
DOI:
10.1038/nchembio.252
[PubMed - indexed for MEDLINE]
Free PMC Article
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