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Biochim Biophys Acta. 2010 Feb;1804(2):263-74. doi: 10.1016/j.bbapap.2009.11.005. Epub 2009 Nov 13.

Superoxide dismutases-a review of the metal-associated mechanistic variations.

Author information

1
Plant Genetic Engineering Group, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Quinta do Marquês, 2784-505 Oeiras, Portugal.

Abstract

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion controlled rate constants via a general mechanism that involves the sequential reduction and oxidation of the metal center, with the concomitant oxidation and reduction of superoxide radicals. That the catalytically active metal can be copper, iron, manganese or, recently, nickel is one of the fascinating features of this class of enzymes. In this review, we describe these enzymes in terms of the details of their catalytic properties, with an emphasis on the mechanistic differences between the enzymes. The focus here will be concentrated mainly on two of these enzymes, copper, zinc superoxide dismutase and manganese superoxide dismutase, and some relatively subtle variations in the mechanisms by which they function.

PMID:
19914406
DOI:
10.1016/j.bbapap.2009.11.005
[Indexed for MEDLINE]

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