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FEBS Lett. 2009 Dec 17;583(24):3959-65. doi: 10.1016/j.febslet.2009.11.032.

Fungal regulatory evolution: cis and trans in the balance.

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1
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 01242, USA.

Abstract

Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis- and trans-factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation.

PMID:
19914250
PMCID:
PMC2823291
DOI:
10.1016/j.febslet.2009.11.032
[Indexed for MEDLINE]
Free PMC Article
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