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FEBS Lett. 2010 Jan 21;584(2):359-65. doi: 10.1016/j.febslet.2009.11.038.

Formation of the tRNALys packaging complex in HIV-1.

Author information

1
Lady Davis Institute for Medical Research, McGill AIDS Centre, Jewish General Hospital, 3755 Cote St. Catherine Rd., Montreal, Quebec, Canada H3T1E2. lawrence.kleiman@mcgill.ca

Abstract

Human immunodeficiency virus 1 (HIV-1) uses a host cell tRNA(Lys,3) molecule to prime reverse transcription of the viral RNA genome into double-stranded DNA prior to integration into the host genome. All three human tRNA(Lys) isoacceptors along with human lysyl-tRNA synthetase (LysRS) are selectively packaged into HIV-1. Packaging of LysRS requires the viral Gag polyprotein and incorporation of tRNA(Lys) additionally requires the Gag-Pol precursor. A model that incorporates the known interactions between components of the putative packaging complex is presented. The molecular interactions that direct assembly of the tRNA(Lys)/LysRS packaging complex hold promise for the development of new anti-viral agents.

PMID:
19914238
PMCID:
PMC2820394
DOI:
10.1016/j.febslet.2009.11.038
[Indexed for MEDLINE]
Free PMC Article
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