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Neuron. 2009 Nov 12;64(3):303-9. doi: 10.1016/j.neuron.2009.10.020.

MicroRNAs potentiate neural development.

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1
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USA.

Abstract

MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any other tissue, where they are hypothesized to function in neural development. Recent reports describing the effects of specific miRNAs during development, and studies employing miRNA depletion as neural commitment proceeds in the embryo, support a requisite role for miRNAs in cell-fate decisions and provide clues to their function in other aspects of nervous system development.

PMID:
19914179
DOI:
10.1016/j.neuron.2009.10.020
[Indexed for MEDLINE]
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