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Environ Res. 2010 Jan;110(1):112-7. doi: 10.1016/j.envres.2009.10.009.

Can living in the surroundings of a petrochemical complex be a risk factor for autoimmune thyroid disease?

Author information

1
Epidemiological Surveillance Center-CVE/SES/SP, Arnaldo, 351, 6(o) Andar, São Paulo/SP-CEP:01246-000, Brasil. umbelino.freitas@gmail.com

Abstract

BACKGROUND:

Based on a suspicion raised by a health professional and due to a subsequent legal request, a cross-sectional study was made with a comparison group to investigate a possible excess of Hashimoto's thyroiditis-HT and antibodies-ATA in the surroundings of a Petrochemical Complex.

METHODS:

People of both sexes aged over 20 years were investigated in a random sample of residents in the area surrounding the Petrochemical Complex. Controls were investigated in an area with steel industries. In the areas searched, participants were chosen randomly and stratified a priori by sex and age group. As a result, 90.5% of the expected sample was obtained, totaling 1533 individuals. HT and ATA prevalences were compared by the chi-square test. Logistic regression was used to control the possible confounding factors for HT and ATA.

RESULTS:

Both TH (9.3%) and ATA (17.6%) prevalences were higher in the Petrochemical Complex area than in the control area (3.9% and 10.3%, respectively). After controlling the possible confounding factors, the POR for living in the surroundings of the Complex and presenting HT was 2.39 (CI95%: 1.42-4.03). According to the ATA criterion, the POR for living in the surroundings of the Complex was 1.78 (CI95%: 1.23-2.60).

CONCLUSIONS:

The authors have found higher prevalence and risk of developing thyroiditis and anti-thyroid antibodies among residents of areas surrounding the Petrochemical Complex and think these findings need to be further studied in similar areas.

PMID:
19913221
DOI:
10.1016/j.envres.2009.10.009
[Indexed for MEDLINE]

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